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This ﬁnd- sic cellular pathway purchase avana 50 mg mastercard, respectively) generic avana 50 mg, but it may be assumed that ing opens new perspectives for the treatment of hearing loss and these mechanisms are more or less under statistical control in that justiﬁes the efforts to encapsulate nucleotides encoding the Math1 dependent on the characteristics of the stimulus the extent of cell gene within the nanostructures for the treatment of deafness. Each of these mechanisms provides the possibility to hearing after noise trauma has been observed in humans, implying reduce and, in some cases, to prevent cochlear cell death through that humans may also have the capacity to regain hearing function active intervention with pharmacotherapy. However, the mechanisms behind the recovery have not yet Recently, many researchers have investigated the role of been fully delineated. There is, however, substantial evidence that antioxidant agents in different models of peripheral hearing cochlear damage induced by noise can be prevented by the appli- disorders. It has been found that antioxidants protect the cation of different pharmacologically active substances (12). Thus, cochlea from noise-induced trauma, as well as cisplatin and there are grounds to expect that hearing disorders in mammals aminoglycoside exposure (2–4). The would mainly be caused by metabolic mechanisms while at outer hair cells are activated and react in a linear manner to higher levels, mechanical mechanisms would predominate. As sinusoidal sound stimulation with one impulse to one sinusoid changes in homeostasis may also occur in mechanical trauma up to 1000 Hz. At higher frequencies, other mechanisms are and the effects of metabolic stress are also likely to be expressed involved in coding the ampliﬁcation of the signal. These are as mechanical damage, it is not meaningful to make a strict sep- not known in detail. Cell tractions of the outer hair cell bodies amplify the basilar mem- death is a result of either apoptosis or necrosis. Apoptosis is a brane vibration and transduce the vibration to shear forces that strictly controlled process to eliminate dysfunctional cells with- will activate the inner hair cells. It can be viewed as a coun- enhanced basilar membrane vibration is transmitted into the terbalance to cell division, and a disturbance may, for example, central auditory system and is perceived as sound. Necrosis on the supporting cells is not clear yet but they may serve as a sup- the other hand is a more passive type of cell death, involving a porting organ to provide stability and damping of excessive rapid and disorganised breakdown of a cell, often as a conse- vibration. Damage to the cochlea may also lead to hyperacusis quence of acute trauma (toxic substances, ischaemia, etc.
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